74 Principal Research Scientist Pharmaceutical Development jobs in Kenya
Principal Scientist - Drug Discovery & Development
Posted 14 days ago
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Job Description
Key Responsibilities:
- Design and execute innovative research strategies to identify and validate novel drug targets and therapeutic candidates.
- Lead projects focused on small molecule or biologic drug discovery, from hit identification to lead optimization.
- Develop and implement cutting-edge assays and experimental methodologies relevant to target validation and compound screening.
- Analyze complex biological data, interpret results, and make informed decisions to advance research programs.
- Collaborate closely with internal teams (e.g., medicinal chemistry, pharmacology, DMPK) and external partners to drive project progression.
- Provide scientific leadership and mentorship to research associates and junior scientists in a remote environment.
- Prepare high-quality scientific reports, publications, and presentations for internal review and external dissemination.
- Contribute to the strategic direction of the R&D pipeline and identify new opportunities for innovation.
- Ensure all research activities are conducted in compliance with ethical standards and regulatory guidelines.
Qualifications:
- Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- Minimum of 10 years of post-doctoral and/or industry experience in pharmaceutical drug discovery.
- Demonstrated expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) and/or a specific modality (e.g., small molecules, biologics, gene therapy).
- Proven track record of successfully progressing drug candidates through discovery and pre-clinical development.
- Extensive experience with various molecular and cellular biology techniques, assay development, and high-throughput screening.
- Strong understanding of drug metabolism, pharmacokinetics (DMPK), and toxicology principles.
- Excellent analytical, critical thinking, and problem-solving skills.
- Exceptional written and verbal communication skills, with a talent for scientific storytelling.
- Ability to lead research projects, mentor junior scientists, and collaborate effectively in a remote, cross-functional team setting.
Remote Principal Scientist - Drug Discovery & Development
Posted 7 days ago
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Job Description
Responsibilities:
- Lead and direct cutting-edge research programs focused on identifying and validating novel drug targets.
- Design and oversee the synthesis and optimization of small molecule drug candidates.
- Develop and implement robust preclinical study designs to assess drug efficacy, safety, and pharmacokinetics.
- Interpret complex experimental data and guide research strategies for progression.
- Mentor and manage a team of scientists and research associates, fostering a collaborative and innovative environment.
- Collaborate effectively with internal and external partners, including CROs and academic institutions.
- Contribute significantly to the preparation of regulatory submissions and intellectual property filings.
- Stay at the forefront of scientific advancements in relevant therapeutic areas and drug discovery technologies.
- Present research findings and strategic plans to senior management and scientific advisory boards.
- Ensure compliance with all relevant ethical, safety, and regulatory guidelines.
- Ph.D. in Pharmacology, Medicinal Chemistry, Biochemistry, or a closely related field.
- Minimum of 10 years of progressive experience in drug discovery and development within the pharmaceutical or biotechnology industry.
- Demonstrated success in advancing drug candidates from discovery through preclinical development.
- In-depth knowledge of drug target identification, validation, and lead optimization strategies.
- Extensive experience with various assay development, screening technologies, and preclinical models.
- Strong leadership, team management, and interpersonal skills.
- Exceptional analytical, critical thinking, and problem-solving abilities.
- Excellent written and verbal communication skills, adept at remote scientific discourse and reporting.
- Proven ability to manage complex research projects, budgets, and timelines in a remote setting.
- A deep understanding of the pharmaceutical R&D landscape and regulatory requirements.
Principal Pharmaceutical Scientist - Drug Discovery and Development
Posted 17 days ago
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Job Description
Responsibilities:
- Lead and direct research projects focused on identifying and validating novel drug targets and developing innovative small molecule or biologic drug candidates.
- Design, synthesize, and characterize novel chemical entities with therapeutic potential.
- Conduct rigorous preclinical studies, including in vitro and in vivo pharmacology, toxicology, and pharmacokinetic assessments.
- Develop and optimize drug delivery systems and formulation strategies.
- Collaborate effectively with a globally distributed, remote team of chemists, biologists, pharmacologists, and clinicians.
- Analyze and interpret complex experimental data, providing strategic direction for drug discovery programs.
- Author scientific publications, patents, and regulatory documents.
- Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
- Stay at the forefront of scientific advancements in relevant therapeutic areas and drug discovery technologies.
- Contribute to the strategic planning and portfolio management of drug development projects, considering various markets including Embu, Embu, KE , for future commercialization.
- Manage external collaborations with academic institutions and contract research organizations (CROs).
- Ph.D. in Medicinal Chemistry, Pharmacology, Pharmaceutical Sciences, or a closely related field.
- Minimum of 10 years of relevant industry experience in drug discovery and preclinical development.
- Demonstrated expertise in a specific therapeutic area (e.g., oncology, infectious diseases, CNS disorders).
- Strong understanding of drug metabolism and pharmacokinetics (DMPK), toxicology, and regulatory requirements for drug development.
- Proven track record of successfully leading drug discovery projects and advancing candidates into clinical trials.
- Excellent scientific judgment, critical thinking, and problem-solving skills.
- Exceptional written and verbal communication skills, essential for remote collaboration and scientific dissemination.
- Experience with scientific literature databases (e.g., SciFinder, PubMed) and data analysis software.
- Ability to work independently and manage multiple research projects concurrently in a remote setting.
- A strong publication record in peer-reviewed journals and relevant patent filings is highly advantageous.
Principal Research Scientist - Pharmaceutical Development
Posted 21 days ago
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Job Description
Principal Research Scientist - Pharmaceutical Development - Remote
Posted 19 days ago
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Job Description
Key Responsibilities:
- Lead and manage research projects from conceptualization through to preclinical development.
- Design, execute, and interpret complex biological and pharmacological experiments.
- Develop and validate new assays and methodologies for drug discovery and characterization.
- Analyze and report research findings to senior management and cross-functional teams.
- Mentor and guide junior research scientists and technicians.
- Contribute to the writing of research protocols, study reports, and scientific publications.
- Collaborate with external partners, academic institutions, and contract research organizations (CROs).
- Ensure research activities comply with Good Laboratory Practice (GLP) and other relevant regulations.
- Identify and evaluate potential new drug targets and therapeutic strategies.
- Stay current with the latest advancements in pharmaceutical sciences and relevant therapeutic areas.
- Ph.D. in Pharmacology, Biochemistry, Molecular Biology, Pharmaceutical Sciences, or a related field.
- Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Demonstrated track record of leading successful drug discovery and development projects.
- Extensive experience in experimental design, data analysis, and interpretation using statistical software.
- Proven expertise in (Specify relevant area, e.g., small molecule drug discovery, biologics, targeted therapies).
- Strong publication record in peer-reviewed journals.
- Excellent written and verbal communication skills, with the ability to present complex scientific data effectively.
- Demonstrated leadership and team management abilities.
- Ability to work independently and collaboratively in a remote research environment.
- Strong understanding of drug development processes and regulatory requirements.
Principal Scientist - Pharmaceutical Research & Development
Posted 21 days ago
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Job Description
Responsibilities:
- Lead and manage research projects from target identification through preclinical development.
- Design, execute, and interpret complex experiments to evaluate novel drug candidates.
- Develop and validate innovative assays and methodologies for drug discovery.
- Analyze and synthesize data from various sources to drive project decisions and strategy.
- Collaborate closely with cross-functional teams, including medicinal chemistry, biology, pharmacology, and clinical development.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and innovation.
- Prepare high-quality scientific reports, presentations, and publications.
- Contribute to the intellectual property strategy through patent filings.
- Stay abreast of the latest scientific literature, emerging technologies, and competitive intelligence.
- Represent the company at scientific conferences and engage with external key opinion leaders.
- Ensure compliance with all regulatory requirements and safety protocols.
- Contribute to the strategic direction of the R&D pipeline.
- Manage external collaborations and CROs as needed.
Qualifications:
- PhD in Pharmacology, Biochemistry, Molecular Biology, or a related life science discipline.
- 10+ years of progressive experience in pharmaceutical R&D, with a strong focus on drug discovery and development.
- Demonstrated expertise in at least one major therapeutic area (e.g., oncology, immunology, infectious diseases).
- Proven track record of leading successful drug discovery programs, leading to preclinical candidates.
- Extensive experience with various experimental techniques and analytical methods relevant to drug discovery.
- Strong understanding of drug development processes and regulatory pathways.
- Excellent leadership, communication, and interpersonal skills, with the ability to inspire and guide a team.
- Strong publication record in peer-reviewed journals and presentations at international conferences.
- Ability to think critically, solve complex problems, and make data-driven decisions.
- Experience working in a collaborative, fast-paced, and remote research environment.
- This is a fully remote position, offering flexibility and global reach.
Principal Pharmaceutical Scientist - CMC Development
Posted 20 days ago
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Job Description
Responsibilities:
- Lead the CMC strategy and execution for early-stage and late-stage pharmaceutical development projects.
- Oversee process development, optimization, and scale-up activities for drug substance and drug product manufacturing.
- Design and execute studies for characterization, impurity profiling, and stability of pharmaceutical compounds.
- Develop and validate analytical methods to support process development, quality control, and regulatory filings.
- Collaborate closely with discovery, pre-clinical, clinical, and manufacturing teams to ensure seamless project progression.
- Author and review CMC sections of regulatory submissions (e.g., INDs, NDAs, BLAs) and prepare responses to health authority queries.
- Provide expert technical guidance on process challenges, quality investigations, and troubleshooting.
- Manage external contract manufacturing organizations (CMOs) and contract research organizations (CROs) involved in CMC activities.
- Stay current with regulatory guidelines (FDA, EMA, ICH) and industry best practices in pharmaceutical development.
- Mentor junior scientists and contribute to the scientific leadership and strategic direction of the CMC group.
- Ph.D. in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
- Minimum of 8 years of progressive experience in pharmaceutical CMC development, with a strong track record of successfully progressing candidates through regulatory milestones.
- In-depth knowledge of drug substance and drug product development, process chemistry, formulation, and analytical sciences.
- Proven experience in developing and validating analytical methods (HPLC, GC, MS, spectroscopy, etc.).
- Strong understanding of cGMP requirements and pharmaceutical regulatory landscape.
- Expertise in managing CMOs/CROs and overseeing outsourced development activities.
- Excellent scientific judgment, problem-solving skills, and strategic thinking.
- Exceptional written and verbal communication skills, with extensive experience in preparing regulatory documents.
- Demonstrated ability to lead cross-functional teams and drive projects in a remote environment.
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Principal Bioinformatician - Drug Discovery
Posted 2 days ago
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Job Description
Key Responsibilities:
- Design, develop, and maintain robust bioinformatics pipelines for analyzing diverse biological data, including genomics, transcriptomics, proteomics, and metabolomics.
- Apply machine learning and statistical modeling techniques to identify drug targets, predict drug efficacy, and understand mechanisms of action.
- Integrate and interpret multi-omics data to gain comprehensive insights into disease biology.
- Collaborate closely with medicinal chemists, biologists, and pharmacologists to guide drug discovery efforts.
- Develop and implement strategies for data management, curation, and quality control.
- Present complex computational findings clearly and effectively to both technical and non-technical stakeholders.
- Stay abreast of the latest advancements in bioinformatics, computational biology, and drug discovery.
- Mentor junior bioinformaticians and contribute to team development.
- Ph.D. or equivalent research experience in Bioinformatics, Computational Biology, Computer Science, Statistics, or a related quantitative field.
- Minimum of 7 years of experience in bioinformatics, with a significant focus on drug discovery or related R&D settings.
- Expertise in scripting languages (e.g., Python, R) and experience with bioinformatic tools and databases.
- Demonstrated experience with machine learning algorithms and their application to biological data.
- Strong understanding of molecular biology, genetics, and disease pathways.
- Proven ability to manage complex projects, work independently, and deliver results in a remote setting.
- Excellent communication, collaboration, and problem-solving skills.
- Experience with large-scale data analysis and high-performance computing environments is essential.
Principal Scientist, Drug Discovery
Posted 21 days ago
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Job Description
Responsibilities:
- Lead and manage complex drug discovery projects, from target identification and validation to lead optimization.
- Design and execute in vitro and in vivo studies to evaluate compound efficacy, safety, and pharmacokinetic profiles.
- Develop and implement cutting-edge assays and experimental models relevant to various therapeutic areas.
- Analyze and interpret complex experimental data, draw meaningful conclusions, and present findings to senior management and scientific teams.
- Collaborate closely with medicinal chemists, toxicologists, and other R&D functions to advance drug candidates.
- Stay abreast of the latest scientific literature, industry trends, and emerging technologies in drug discovery.
- Mentor and guide junior scientists, fostering their professional development and ensuring high-quality research execution.
- Contribute to the strategic direction of the R&D portfolio and identify new opportunities for innovation.
- Prepare and present research findings at international conferences and publish in high-impact peer-reviewed journals.
- Ensure compliance with all relevant regulatory guidelines and ethical standards.
The ideal candidate will possess a Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline, with a minimum of 10 years of post-doctoral research experience in the pharmaceutical industry or a relevant academic setting. A proven track record of successfully leading drug discovery programs and contributing to the advancement of compounds into clinical development is essential. Expertise in a specific therapeutic area (e.g., oncology, immunology, infectious diseases) is highly desirable. Strong understanding of drug development processes, including ADME/Tox, and regulatory pathways is required. Excellent leadership, communication, and interpersonal skills are crucial for effective team management and cross-functional collaboration. This role is based in Kitale, Trans-Nzoia, KE , and offers a hybrid work model for eligible employees, balancing in-lab research with remote strategic planning and data analysis.
Lead Computational Chemist - Drug Discovery
Posted 5 days ago
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Job Description
Key Responsibilities:
- Lead and mentor a team of computational chemists in designing and executing virtual screening campaigns.
- Develop and implement novel computational strategies for hit identification and lead optimization.
- Apply advanced molecular modeling, docking, and simulation techniques to explore chemical space.
- Utilize machine learning and AI algorithms to build predictive models for compound activity, ADMET properties, and selectivity.
- Collaborate closely with medicinal chemists, biologists, and pharmacologists to align computational efforts with project goals.
- Analyze large-scale experimental and computational datasets to extract actionable insights.
- Contribute to the development of internal tools and software for drug discovery workflows.
- Stay updated with the latest trends and technologies in computational chemistry and cheminformatics.
- Present findings and strategies to project teams and senior management.
- Foster a collaborative and innovative research environment within the remote team structure.
- Ph.D. in Computational Chemistry, Cheminformatics, or a closely related field.
- A minimum of 7 years of experience in computational chemistry within the pharmaceutical or biotech industry.
- Proven expertise in molecular modeling software (e.g., Schrödinger Suite, MOE, Discovery Studio) and force fields.
- Strong programming skills in Python, with experience in scientific computing libraries (NumPy, SciPy, Pandas).
- Demonstrated experience with machine learning frameworks (e.g., Scikit-learn, TensorFlow, PyTorch) and their application to chemical data.
- Experience with QSAR modeling, pharmacophore modeling, and virtual screening techniques.
- Excellent understanding of drug discovery principles and processes.
- Exceptional problem-solving skills and the ability to think creatively.
- Outstanding communication and interpersonal skills, with the ability to effectively collaborate in a remote setting.
- A proactive and results-oriented mindset.