164 Senior Pharmaceutical Research Scientist Drug Discovery jobs in whatjobs
Senior Pharmaceutical Research Scientist (Drug Discovery)
Posted 20 days ago
Job Viewed
Job Description
Our client, a leading Pharmaceutical company, is seeking a highly accomplished Senior Pharmaceutical Research Scientist to join their cutting-edge, fully remote drug discovery team. This role is instrumental in identifying, validating, and advancing novel therapeutic targets and drug candidates. You will lead research initiatives, design and execute complex experiments in medicinal chemistry and pharmacology, and contribute to the development of innovative medicines. The ideal candidate possesses a profound understanding of disease biology, drug discovery processes, and relevant therapeutic areas. You will collaborate extensively with a global network of scientists, clinicians, and project teams to accelerate the drug development pipeline.
Key Responsibilities:
Key Responsibilities:
- Lead the design and execution of drug discovery projects, from target identification and validation through to lead optimization.
- Develop and implement innovative medicinal chemistry strategies to synthesize novel small molecules with desired pharmacological profiles.
- Conduct in vitro and in vivo studies to assess drug efficacy, pharmacokinetics, and safety.
- Utilize structure-based drug design, computational chemistry, and other advanced techniques to guide compound design.
- Collaborate with biologists, pharmacologists, and toxicologists to characterize drug candidates and elucidate mechanisms of action.
- Manage research timelines, budgets, and resources for assigned projects.
- Supervise and mentor junior research scientists and laboratory personnel.
- Analyze and interpret complex experimental data, drawing scientifically sound conclusions.
- Prepare comprehensive research reports, manuscripts for publication, and presentations for scientific conferences and internal reviews.
- Contribute to intellectual property generation through patent filings.
- Stay abreast of the latest scientific advancements and emerging technologies in pharmaceutical R&D.
- Ensure all research activities adhere to strict regulatory guidelines (e.g., GLP) and ethical standards.
- Participate in cross-functional project teams, providing scientific expertise and strategic input.
- Foster a collaborative and innovative research environment.
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Senior Pharmaceutical Research Scientist - Drug Discovery
Posted 20 days ago
Job Viewed
Job Description
Our client, a leading innovator in the pharmaceutical industry, is seeking a highly skilled and experienced Senior Pharmaceutical Research Scientist to join their drug discovery team. This is a fully remote position, allowing you to contribute your expertise to groundbreaking research from your preferred location. You will be instrumental in identifying, validating, and developing novel therapeutic targets and small molecules for unmet medical needs. Your deep understanding of medicinal chemistry, pharmacology, and drug development processes will be critical.
Responsibilities:
Responsibilities:
- Lead and conduct cutting-edge research in drug discovery, focusing on identifying and validating novel therapeutic targets.
- Design and synthesize novel small molecules with desired pharmacological profiles using modern medicinal chemistry techniques.
- Develop and optimize in vitro and in vivo assays to evaluate compound efficacy, selectivity, and pharmacokinetic properties.
- Collaborate closely with cross-functional teams, including biologists, pharmacologists, toxicologists, and clinical development scientists, to advance drug candidates through the pipeline.
- Analyze experimental data, interpret results, and present findings at internal meetings and scientific conferences.
- Manage research projects, including planning, resource allocation, and timeline management.
- Mentor and guide junior scientists and research associates.
- Stay abreast of the latest scientific literature, emerging technologies, and industry trends in drug discovery and development.
- Contribute to patent applications and scientific publications.
- Ensure all research activities are conducted in compliance with ethical guidelines and regulatory requirements.
- Ph.D. in Medicinal Chemistry, Pharmacology, Organic Chemistry, or a related life sciences discipline.
- Minimum of 7 years of hands-on experience in drug discovery and development, with a strong track record of contributing to successful preclinical candidates.
- Proven expertise in medicinal chemistry, including structure-activity relationship (SAR) analysis, lead optimization, and drug design strategies.
- Experience with various pharmacological assays and techniques, both in vitro and in vivo.
- Proficiency in modern synthetic organic chemistry and analytical techniques (NMR, MS, HPLC).
- Strong understanding of pharmacokinetic (PK) and pharmacodynamic (PD) principles.
- Excellent problem-solving, critical thinking, and data analysis skills.
- Exceptional written and verbal communication skills, with the ability to articulate complex scientific concepts effectively in a remote setting.
- Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
This advertiser has chosen not to accept applicants from your region.
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Senior Pharmaceutical Research Scientist (Drug Discovery)
Posted 20 days ago
Job Viewed
Job Description
Our client, a leading biopharmaceutical company dedicated to discovering and developing life-changing therapies, is seeking a highly innovative Senior Pharmaceutical Research Scientist to join their fully remote drug discovery team. This is an exceptional opportunity for a seasoned scientist to contribute to groundbreaking research in a dynamic, virtual environment. You will be instrumental in identifying and validating novel drug targets, designing and synthesizing potential therapeutic compounds, and conducting preclinical studies. This remote-first position requires a strong scientific background, exceptional research skills, and the ability to collaborate effectively within a distributed scientific community. Responsibilities include:
- Conceptualizing, designing, and executing innovative research projects aimed at identifying and validating new drug targets for various therapeutic areas.
- Designing, synthesizing, and optimizing novel small molecules and biologics with potential therapeutic activity.
- Developing and implementing in vitro and in vivo assays to evaluate compound efficacy, safety, and pharmacokinetic properties.
- Conducting detailed data analysis, interpreting experimental results, and drawing scientifically sound conclusions.
- Preparing high-quality research reports, manuscripts for publication, and presentations for scientific conferences.
- Collaborating closely with medicinal chemists, biologists, pharmacologists, and other research scientists in a remote setting.
- Managing research projects, prioritizing tasks, and ensuring timely completion of milestones.
- Staying abreast of the latest scientific literature, technological advancements, and emerging trends in pharmaceutical research and drug discovery.
- Contributing to the development of intellectual property and patent applications.
- Mentoring and guiding junior research staff.
- Ensuring compliance with all laboratory safety protocols and ethical research standards.
- Ph.D. in Pharmacology, Medicinal Chemistry, Biology, Biochemistry, or a related life science discipline.
- Minimum of 6 years of postdoctoral or industry research experience in drug discovery.
- Proven track record of successful research contributions, demonstrated by publications in reputable peer-reviewed journals and/or patents.
- Extensive experience in experimental design, execution, and data interpretation relevant to drug discovery.
- Proficiency in a range of biological and/or chemical research techniques and instrumentation.
- Strong understanding of disease mechanisms and therapeutic intervention strategies.
- Excellent analytical, critical thinking, and problem-solving skills.
- Exceptional written and verbal communication skills, with the ability to clearly present complex scientific information.
- Demonstrated ability to work independently, manage projects effectively, and collaborate successfully in a remote, team-oriented environment.
- Experience with high-throughput screening (HTS) and structure-based drug design is a significant advantage.
This advertiser has chosen not to accept applicants from your region.
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Senior Pharmaceutical Research Scientist - Drug Discovery
Posted 20 days ago
Job Viewed
Job Description
Our client is a leading pharmaceutical innovator seeking a highly accomplished Senior Pharmaceutical Research Scientist to join their cutting-edge drug discovery team. This is a fully remote position, enabling you to contribute to groundbreaking therapeutic research from anywhere. You will be instrumental in identifying, validating, and characterizing novel drug targets and developing innovative therapeutic molecules. This role requires extensive experience in medicinal chemistry, pharmacology, or a related discipline, combined with a strong track record of scientific publication and contribution to drug development pipelines. The ideal candidate is a strategic thinker, capable of leading research projects, mentoring junior scientists, and collaborating effectively within a dynamic, virtual research environment.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Lead research projects focused on the discovery and development of novel therapeutics for unmet medical needs.
- Design and conduct experiments to identify and validate new drug targets.
- Synthesize and characterize potential drug candidates using advanced medicinal chemistry techniques.
- Develop and implement in vitro and in vivo assays to assess drug efficacy and safety.
- Analyze complex biological and chemical data, interpreting results and making informed decisions.
- Collaborate closely with cross-functional teams, including biologists, pharmacologists, and toxicologists.
- Write high-quality research protocols, reports, and scientific publications.
- Present research findings at internal meetings and external scientific conferences.
- Mentor and guide junior research scientists, fostering a collaborative and innovative research culture.
- Manage project timelines, resources, and budgets effectively.
- Stay abreast of the latest scientific advancements and technological innovations in drug discovery.
Qualifications:
- Ph.D. in Medicinal Chemistry, Pharmacology, Biochemistry, or a related life sciences field.
- Minimum of 7 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Proven track record in drug discovery, with successful contributions to at least one preclinical or clinical candidate.
- Extensive experience in synthetic organic chemistry, compound library design, and SAR studies.
- Proficiency in modern drug discovery technologies and assay development.
- Strong understanding of disease biology and target validation strategies.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, with the ability to effectively present complex scientific information.
- Demonstrated ability to lead research projects and mentor junior scientists.
- Experience working effectively in a remote research setting is highly desirable.
This advertiser has chosen not to accept applicants from your region.
3
Senior Pharmaceutical Research Scientist - Drug Discovery
Posted 20 days ago
Job Viewed
Job Description
Our client is seeking a highly motivated and experienced Senior Pharmaceutical Research Scientist to join their dynamic drug discovery team. This is a fully remote, critical role requiring a deep understanding of medicinal chemistry, pharmacology, and drug development processes. You will be instrumental in identifying and validating novel therapeutic targets, designing and synthesizing potential drug candidates, and optimizing their pharmacological profiles.
Key Responsibilities:
Qualifications:
This role is based remotely, offering the flexibility to work from anywhere within the specified guidelines. Our client is committed to fostering a diverse and inclusive work environment and providing unparalleled opportunities for professional growth.
Key Responsibilities:
- Lead innovative research projects focused on discovering and developing new pharmaceutical agents for unmet medical needs.
- Design and execute complex in vitro and in vivo experiments to assess drug efficacy, safety, and pharmacokinetic properties.
- Utilize advanced techniques in medicinal chemistry for the synthesis and characterization of small molecules.
- Collaborate effectively with cross-functional teams, including biologists, toxicologists, and clinical scientists, to advance projects from discovery to preclinical development.
- Analyze and interpret experimental data, prepare high-quality scientific reports, and present findings at internal and external scientific forums.
- Stay abreast of the latest scientific literature, emerging technologies, and competitive intelligence in relevant therapeutic areas.
- Mentor junior scientists and contribute to the overall scientific strategy of the drug discovery unit.
- Ensure compliance with all relevant regulatory guidelines and company policies.
Qualifications:
- Ph.D. in Medicinal Chemistry, Pharmacology, Biochemistry, or a related life science discipline.
- A minimum of 5-7 years of progressive experience in pharmaceutical research and development, with a strong track record in drug discovery.
- Proven expertise in small molecule synthesis, structure-activity relationship (SAR) studies, and lead optimization.
- Hands-on experience with various biological assay development and validation techniques.
- Proficiency in data analysis software and scientific literature databases.
- Excellent problem-solving skills, creativity, and a passion for scientific innovation.
- Exceptional written and verbal communication skills, with the ability to articulate complex scientific concepts clearly.
- Demonstrated ability to work independently and as part of a collaborative, remote team.
- Experience in (mention a specific therapeutic area, e.g., oncology, immunology, CNS) is highly desirable.
This role is based remotely, offering the flexibility to work from anywhere within the specified guidelines. Our client is committed to fostering a diverse and inclusive work environment and providing unparalleled opportunities for professional growth.
This advertiser has chosen not to accept applicants from your region.
4
Senior Pharmaceutical Research Scientist - Drug Discovery
Posted 20 days ago
Job Viewed
Job Description
Our client, a globally recognized pharmaceutical company, is seeking a highly motivated and experienced Senior Pharmaceutical Research Scientist to drive their drug discovery initiatives. This is a fully remote position, enabling you to contribute to life-saving research from any location. The successful candidate will be instrumental in identifying novel therapeutic targets, designing and synthesizing candidate compounds, and advancing potential drugs through the preclinical development pipeline. Your expertise in medicinal chemistry, pharmacology, or a related discipline will be critical. This role demands a deep understanding of drug discovery processes, assay development, and data analysis. You will collaborate with a multidisciplinary team of scientists, chemists, biologists, and pharmacologists to accelerate the pace of innovation. Responsibilities include leading research projects, interpreting experimental results, preparing scientific reports, and contributing to regulatory submissions. The ability to manage research projects, mentor junior scientists, and effectively communicate complex scientific information is essential. We are looking for a strategic and innovative researcher with a strong publication record and a passion for developing new medicines. The ideal candidate possesses excellent laboratory skills, a comprehensive knowledge of therapeutic areas, and a commitment to scientific rigor. This is an exceptional opportunity to make a significant impact on global health through cutting-edge pharmaceutical research, all within a flexible, remote work environment.
Responsibilities:
Responsibilities:
- Lead and execute drug discovery projects from target identification to lead optimization
- Design, synthesize, and characterize novel small molecules with therapeutic potential
- Develop and validate biochemical and cellular assays for drug screening and efficacy testing
- Conduct in vivo studies to assess pharmacokinetic and pharmacodynamic properties of drug candidates
- Analyze and interpret complex experimental data, and prepare comprehensive research reports
- Collaborate effectively with cross-functional teams (chemistry, biology, DMPK, toxicology)
- Identify and evaluate new drug targets and therapeutic opportunities
- Contribute to patent applications and scientific publications
- Mentor and guide junior research scientists and technicians
- Ensure compliance with all laboratory safety regulations and GxP guidelines
- Ph.D. in Medicinal Chemistry, Pharmacology, Biochemistry, or a related field
- Minimum of 7 years of progressive experience in pharmaceutical drug discovery
- Proven track record of successfully advancing drug candidates through the discovery pipeline
- Expertise in medicinal chemistry principles, synthetic organic chemistry, and structure-activity relationship (SAR) analysis
- Experience with various drug discovery technologies and techniques (e.g., high-throughput screening, fragment-based drug design)
- Strong understanding of pharmacokinetic and pharmacodynamic principles
- Excellent analytical, problem-solving, and critical thinking skills
- Proficiency in data analysis software and scientific literature databases
- Exceptional written and verbal communication skills, with a strong publication record
- Ability to work independently, manage multiple projects, and thrive in a collaborative research environment
This advertiser has chosen not to accept applicants from your region.
5
Senior Pharmaceutical Research Scientist - Drug Discovery
Posted 20 days ago
Job Viewed
Job Description
Our client, a pioneering biopharmaceutical company, is seeking an accomplished Senior Pharmaceutical Research Scientist to drive groundbreaking drug discovery initiatives. This is a fully remote position, offering an exciting opportunity to contribute to the development of novel therapeutics from anywhere. You will be at the forefront of identifying and validating new drug targets, designing and synthesizing potential drug candidates, and conducting in vitro and in vivo studies to assess efficacy and safety. Your work will directly impact the lives of patients by bringing innovative medicines to market.
Responsibilities include leading research projects from conception through to preclinical development. You will design and execute complex experimental protocols, analyze and interpret scientific data, and present findings at internal and external forums. This involves staying abreast of the latest scientific literature and technological advancements in relevant therapeutic areas, such as oncology, immunology, or infectious diseases. Collaboration is key; you will work closely with a multidisciplinary team of chemists, biologists, pharmacologists, and toxicologists. Mentoring junior scientists and contributing to the scientific strategy of the research department will also be integral to your role.
The ideal candidate will hold a Ph.D. in Pharmacology, Medicinal Chemistry, Biochemistry, or a closely related life science discipline, with a minimum of 5-7 years of post-doctoral or industry research experience in drug discovery. A proven track record of successful target validation and lead optimization is essential. Expertise in specific therapeutic areas and hands-on experience with relevant assay development, molecular biology techniques, and preclinical models are required. Strong analytical and problem-solving skills, coupled with excellent written and oral communication abilities, are crucial for disseminating research findings. Familiarity with regulatory guidelines and experience in preparing documents for regulatory submissions are advantageous. This role offers the chance to shape the future of medicine within a flexible, remote working environment, contributing to advancements from your location, supporting research focused on challenges relevant to populations around Kericho, Kericho, KE .
Responsibilities include leading research projects from conception through to preclinical development. You will design and execute complex experimental protocols, analyze and interpret scientific data, and present findings at internal and external forums. This involves staying abreast of the latest scientific literature and technological advancements in relevant therapeutic areas, such as oncology, immunology, or infectious diseases. Collaboration is key; you will work closely with a multidisciplinary team of chemists, biologists, pharmacologists, and toxicologists. Mentoring junior scientists and contributing to the scientific strategy of the research department will also be integral to your role.
The ideal candidate will hold a Ph.D. in Pharmacology, Medicinal Chemistry, Biochemistry, or a closely related life science discipline, with a minimum of 5-7 years of post-doctoral or industry research experience in drug discovery. A proven track record of successful target validation and lead optimization is essential. Expertise in specific therapeutic areas and hands-on experience with relevant assay development, molecular biology techniques, and preclinical models are required. Strong analytical and problem-solving skills, coupled with excellent written and oral communication abilities, are crucial for disseminating research findings. Familiarity with regulatory guidelines and experience in preparing documents for regulatory submissions are advantageous. This role offers the chance to shape the future of medicine within a flexible, remote working environment, contributing to advancements from your location, supporting research focused on challenges relevant to populations around Kericho, Kericho, KE .
This advertiser has chosen not to accept applicants from your region.
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Senior Pharmaceutical Research Scientist - Drug Discovery
Posted 20 days ago
Job Viewed
Job Description
Our client, a pioneering pharmaceutical company at the forefront of medical innovation, is seeking a highly accomplished Senior Pharmaceutical Research Scientist to join their dedicated, fully remote drug discovery team. This critical role will involve leading and executing cutting-edge research projects aimed at identifying and validating novel therapeutic targets. You will be instrumental in advancing the company's pipeline of groundbreaking medicines. The ideal candidate possesses a Ph.D. in Pharmacology, Biochemistry, Molecular Biology, or a related life science discipline, coupled with extensive postdoctoral and industry experience in drug discovery research. Proven expertise in molecular biology techniques, assay development, high-throughput screening, and data analysis is essential. As a remote-first scientist, you will collaborate closely with computational biologists, medicinal chemists, and clinical development teams using advanced virtual collaboration platforms and data-sharing tools. Your responsibilities will include designing and conducting complex experiments, interpreting experimental results, presenting findings at scientific meetings, and contributing to patent applications and scientific publications. You will also mentor junior researchers and contribute to the strategic direction of the research department. A deep understanding of disease mechanisms and a track record of successfully advancing drug candidates through the early stages of development are highly desirable. This is an exceptional opportunity to contribute to significant advancements in healthcare from the convenience of a remote setting, driving innovation and making a tangible impact on patient lives. We are seeking a driven, scientifically rigorous individual with a passion for discovery. This role, although linked to our client's presence in **Mlolongo, Machakos, KE**, is a fully remote position.
This advertiser has chosen not to accept applicants from your region.
7
Senior Pharmaceutical Research Scientist (Drug Discovery)
Posted 20 days ago
Job Viewed
Job Description
Our client is a pioneering pharmaceutical research organization seeking a highly accomplished Senior Pharmaceutical Research Scientist to lead critical drug discovery initiatives. This is a fully remote position, offering a unique opportunity to contribute to groundbreaking therapeutic advancements from your home laboratory or dedicated workspace. The successful candidate will possess extensive experience in small molecule drug discovery, medicinal chemistry, and early-stage pharmaceutical R&D. You will play a pivotal role in identifying novel drug targets, designing and synthesizing potent lead compounds, and advancing candidates through the preclinical pipeline. We are looking for an innovative thinker with a strong publication record and a passion for improving human health.
Responsibilities:
Responsibilities:
- Lead and execute medicinal chemistry programs aimed at identifying and optimizing novel small molecule drug candidates for various therapeutic areas.
- Design and synthesize diverse chemical libraries and target compounds using modern synthetic organic chemistry techniques.
- Utilize structure-activity relationship (SAR) studies and computational chemistry tools to guide lead optimization efforts.
- Collaborate closely with biologists, pharmacologists, and toxicologists to assess the efficacy, safety, and pharmacokinetic properties of lead compounds.
- Develop and validate in vitro and in vivo assays to evaluate compound activity and mechanisms of action.
- Stay abreast of the latest scientific literature, emerging technologies, and competitive landscape in relevant therapeutic areas.
- Manage research projects, including setting objectives, developing timelines, and allocating resources effectively.
- Prepare comprehensive research reports, manuscripts for publication, and presentations for scientific conferences and internal stakeholders.
- Contribute to patent filings and intellectual property strategy.
- Mentor and guide junior research scientists and technicians, fostering a collaborative and productive research environment.
- Ensure compliance with all laboratory safety regulations, ethical guidelines, and company policies.
- Propose and pursue innovative research ideas to expand the company's drug discovery portfolio.
- Effectively communicate complex scientific data and concepts to diverse audiences.
- Participate in cross-functional team meetings and contribute to strategic R&D planning.
- Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmacology, or a closely related discipline.
- Minimum of 7 years of post-doctoral and/or industry experience in drug discovery, with a strong focus on medicinal chemistry.
- Proven track record of successfully advancing drug candidates from hit identification to preclinical development.
- Extensive experience in modern synthetic organic chemistry, including multi-step synthesis, purification, and characterization of small molecules.
- Proficiency in SAR analysis, computational chemistry tools, and various drug discovery assay technologies.
- Deep understanding of pharmacokinetic (PK) and pharmacodynamic (PD) principles.
- Excellent problem-solving, analytical, and critical-thinking skills.
- Strong publication record in peer-reviewed journals and experience with patent applications.
- Exceptional written and verbal communication skills, with the ability to present complex scientific information clearly.
- Proven ability to lead research projects and mentor junior scientists in a remote setting.
- Familiarity with therapeutic areas such as oncology, immunology, or infectious diseases is desirable.
- Experience with biologics or other therapeutic modalities is a plus.
This advertiser has chosen not to accept applicants from your region.
8
Senior Pharmaceutical Research Scientist - Drug Discovery
Posted 20 days ago
Job Viewed
Job Description
Our client, a leading pharmaceutical company dedicated to discovering and developing life-changing medicines, is looking for an experienced Senior Pharmaceutical Research Scientist to join their fully remote drug discovery team. This is an exciting opportunity to contribute to innovative research in an area critical to advancing human health. You will play a key role in the early stages of drug discovery, from target identification and validation through to lead optimization. The ideal candidate will possess a strong background in medicinal chemistry, pharmacology, or a related discipline, with a proven track record of successfully contributing to drug development programs. Your responsibilities will include designing and synthesizing novel compounds, evaluating their biological activity and pharmacokinetic properties, and collaborating closely with multidisciplinary teams to advance potential drug candidates. You will be expected to stay abreast of the latest scientific literature and technological advancements in pharmaceutical research, and to contribute to the strategic planning of research projects. This role requires excellent experimental design skills, robust analytical capabilities, and a deep understanding of drug discovery processes. The ability to troubleshoot experiments, interpret complex data, and communicate scientific findings effectively to both scientific and management audiences is essential. The fully remote nature of this position allows for significant flexibility, enabling you to contribute to impactful research from your home office. We are seeking a highly motivated and results-oriented scientist who is passionate about making a difference in patient lives.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Lead and contribute to drug discovery projects, focusing on target validation and lead optimization.
- Design, synthesize, and characterize novel chemical entities with therapeutic potential.
- Evaluate the efficacy, safety, and pharmacokinetic properties of drug candidates in preclinical models.
- Collaborate with biologists, chemists, and other scientists in a multidisciplinary team environment.
- Develop and implement assays for screening and characterizing compounds.
- Analyze and interpret experimental data, and present findings to project teams and stakeholders.
- Contribute to the preparation of research reports, patents, and publications.
- Stay current with scientific literature and emerging trends in pharmaceutical research.
Qualifications:
- PhD in Medicinal Chemistry, Pharmacology, Organic Chemistry, or a related field.
- Minimum of 6 years of experience in pharmaceutical drug discovery research.
- Proven track record of contributing to successful drug discovery programs.
- Expertise in synthetic organic chemistry and modern medicinal chemistry principles.
- Experience with *in vitro* and *in vivo* assay development and execution.
- Strong understanding of ADME/PK principles and drug metabolism.
- Excellent analytical, problem-solving, and critical thinking skills.
- Proficiency in data analysis and scientific reporting.
- Strong communication and collaboration skills for remote team integration.
This advertiser has chosen not to accept applicants from your region.
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